Dopamine D1 and D2 receptors regulate extracellular lactate and glucose concentrations in the nucleus accumbens.

@article{Uehara2007DopamineDA,
  title={Dopamine D1 and D2 receptors regulate extracellular lactate and glucose concentrations in the nucleus accumbens.},
  author={Takashi Uehara and Tomiki Sumiyoshi and Hiroko Itoh and Masayoshi Kurachi},
  journal={Brain research},
  year={2007},
  volume={1133 1},
  pages={193-9}
}
Glucose and lactate have been shown to play a significant role in energy metabolism in the brain. In the present study, the relationship between extracellular glucose and lactate concentrations in the nucleus accumbens (NAC) was determined with in vivo microdialysis technique. We further evaluated the effect of dopamine (DA) receptor agonists on energy metabolism. Extracellular glucose levels were increased following inactivation of neurons by tetrodotoxin (TTX) perfusion, whereas neural… CONTINUE READING
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