Dopamine D-1/D-5 receptor activation is required for long-term potentiation in the rat neostriatum in vitro.

@article{Kerr2001DopamineDR,
  title={Dopamine D-1/D-5 receptor activation is required for long-term potentiation in the rat neostriatum in vitro.},
  author={Jo Nita Q. Kerr and Jeffery R. Wickens},
  journal={Journal of neurophysiology},
  year={2001},
  volume={85 1},
  pages={117-24}
}
Dopamine and glutamate are key neurotransmitters involved in learning and memory mechanisms of the brain. These two neurotransmitter systems converge on nerve cells in the neostriatum. Dopamine modulation of activity-dependent plasticity at glutamatergic corticostriatal synapses has been proposed as a cellular mechanism for learning in the neostriatum. The present research investigated the role of specific subtypes of dopamine receptors in long-term potentiation (LTP) in the corticostriatal… CONTINUE READING
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