Dopamine D₂-agonist rotigotine effects on cortical excitability and central cholinergic transmission in Alzheimer's disease patients.

@article{Martorana2013DopamineDR,
  title={Dopamine D₂-agonist rotigotine effects on cortical excitability and central cholinergic transmission in Alzheimer's disease patients.},
  author={Alessandro Martorana and Francesco Di Lorenzo and Zaira Esposito and Temistocle Lo Giudice and Giorgio Bernardi and Carlo Caltagirone and Giacomo Koch},
  journal={Neuropharmacology},
  year={2013},
  volume={64},
  pages={108-13}
}
Dopamine is a neurotransmitter involved in several brain functions ranging from emotions control, movement organization to memory formation. It is also involved in the regulation of mechanisms of synaptic plasticity. However, its role in Alzheimer's disease (AD) pathogenesis is still puzzling. Several recent line of research instead indicates a clear role for dopamine in both amyloid β formation as well as in cognitive decline progression. In particular it has been shown that dopamine D₂-like… CONTINUE READING

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