Dopamine Agonist-Induced Yawning in Rats: A Dopamine D3 Receptor-Mediated Behavior

  title={Dopamine Agonist-Induced Yawning in Rats: A Dopamine D3 Receptor-Mediated Behavior},
  author={Gregory T Collins and Jeffrey M. Witkin and Amy Hauck Newman and Kjell A. Svensson and Peter Grundt and Jianjing Cao and James H. Woods},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={310 - 319}
A specific role for the dopamine D3 receptor in behavior has yet to be elucidated. We now report that dopamine D2/D3 agonists elicit dose-dependent yawning behavior in rats, resulting in an inverted U-shaped dose-response curve. A series of experiments was directed toward the hypothesis that the induction of yawning is a D3 receptor-mediated effect, whereas the inhibition of the yawning observed at higher doses is due to competing D2 receptor activity. We compared several dopaminergic agonists… 

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