Dopamine-1 receptor stimulation impairs intestinal oxygen utilization during critical hypoperfusion.

@article{Guzmn2003Dopamine1RS,
  title={Dopamine-1 receptor stimulation impairs intestinal oxygen utilization during critical hypoperfusion.},
  author={Jorge A. Guzm{\'a}n and Ariosto E Rosado and James A Kruse},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2003},
  volume={284 2},
  pages={H668-75}
}
Effects of a dopamine-1 (DA-1) receptor agonist on systemic and intestinal oxygen delivery (Do(2))-uptake relationships were studied in anesthetized dogs during sequential hemorrhage. Control (group 1) and experimental animals (group 2) were treated similarly except for the addition of fenoldopam (1.0 microg x kg(-1) x min(-1)) in group 2. Both groups had comparable systemic critical Do(2) (Do(2crit)), but animals in group 2 had a higher gut Do(2crit) (1.12 +/- 1.13 vs. 0.80 +/- 0.09 ml. kg(-1… CONTINUE READING

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