Dopamine (D2/3) receptor agonist positron emission tomography radiotracer [11C]-(+)-PHNO is a D3 receptor preferring agonist in vivo.

@article{Narendran2006DopamineR,
  title={Dopamine (D2/3) receptor agonist positron emission tomography radiotracer [11C]-(+)-PHNO is a D3 receptor preferring agonist in vivo.},
  author={Rajesh Narendran and Mark Slifstein and Olivier Guillin and Yuying C. Hwang and Dah-Ren Hwang and Erica Scher and Stephanie A Reeder and Eugenii A. Rabiner and Marc Laruelle},
  journal={Synapse},
  year={2006},
  volume={60 7},
  pages={
          485-95
        }
}
[11C]PHNO is a recently introduced agonist to image DA D2-like receptors with Positron Emission Tomography (PET). In cats and humans, [11C]PHNO revealed an atypical distribution compared to radiolabeled D2-like antagonists (such as [11C]raclopride) or other D2-like agonists (such as [11C]NPA), as it displayed unusual high binding in the globus pallidus (GP). The goal of this study was to assess the pharmacological nature of the binding of [11C]PHNO in the GP in nonhuman primates. As previously… CONTINUE READING

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