Dopamine: Biphasic Dose Responses

@article{Calabrese2001DopamineBD,
  title={Dopamine: Biphasic Dose Responses},
  author={E. Calabrese},
  journal={Critical Reviews in Toxicology},
  year={2001},
  volume={31},
  pages={563 - 583}
}
  • E. Calabrese
  • Published 2001
  • Biology, Medicine
  • Critical Reviews in Toxicology
The present article indicates that dopamine and/or its agonists induce biphasic dose-response relationships for numerous endpoints. These include locomotion, pain sensitivity, blood pressure, prolactin secretion, oxytocin release, heart rate, memory, and neuronal adenylate cyclase activity. Biphasic responses were reported predominantly with male Sprague-Dawley rats, but also with mice, dogs, monkeys, and humans. Regardless of the model or endpoint the maximum changes from the control were… Expand
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