Dopamine/adenosine interactions related to locomotion and tremor in animal models: possible relevance to parkinsonism.

@article{Salamone2008DopamineadenosineIR,
  title={Dopamine/adenosine interactions related to locomotion and tremor in animal models: possible relevance to parkinsonism.},
  author={John D Salamone and Keita Ishiwari and Adrienne J. Betz and Andrew M. Farrar and Susana Mingote and Laura Font and J{\"o}rg Hockemeyer and Christa E. M{\"u}ller and Merc{\'e} Correa},
  journal={Parkinsonism & related disorders},
  year={2008},
  volume={14 Suppl 2},
  pages={S130-4}
}
Adenosine A(2A) antagonists can exert antiparkinsonian effects in animal models. Recent experiments studied the ability of MSX-3 (an adenosine A(2A) antagonist) to reverse the locomotor suppression and tremor produced by dopamine antagonists in rats. MSX-3 reversed haloperidol-induced suppression of locomotion, and reduced the tremulous jaw movements induced by haloperidol, pimozide, and reserpine. Infusions of MSX-3 into the nucleus accumbens core increased locomotion in haloperidol-treated… CONTINUE READING