Door-to-needle times for tissue plasminogen activator administration and clinical outcomes in acute ischemic stroke before and after a quality improvement initiative.

@article{Fonarow2014DoortoneedleTF,
  title={Door-to-needle times for tissue plasminogen activator administration and clinical outcomes in acute ischemic stroke before and after a quality improvement initiative.},
  author={Gregg C Fonarow and Xin Zhao and Eric E Smith and Jeffrey L. Saver and Mathew J Reeves and Deepak L Bhatt and Ying Xian and Adrian F. Hernandez and Eric D. Peterson and Lee H Schwamm},
  journal={JAMA},
  year={2014},
  volume={311 16},
  pages={1632-40}
}
IMPORTANCE The benefits of intravenous tissue plasminogen activator (tPA) in patients with acute ischemic stroke (AIS) are time dependent and guidelines recommend a door-to-needle (DTN) time of 60 minutes or less. However, studies have found that less than 30% of US patients are treated within this time window. TARGET Stroke was designed as a national quality improvement initiative to improve DTN times for tPA administration in patients with AIS. OBJECTIVES To evaluate DTN times for tPA… CONTINUE READING

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