Donor-specific transplantation tolerance: the paradoxical behavior of CD4+CD25+ T cells.

@article{Graca2004DonorspecificTT,
  title={Donor-specific transplantation tolerance: the paradoxical behavior of CD4+CD25+ T cells.},
  author={Luis Otavio Barroso da Graca and Ala{\'i}n Le Moine and Chun-Yen Lin and Paul Jonathan Fairchild and Stephen Paul Cobbold and Herman Waldmann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 27},
  pages={10122-6}
}
To investigate the antigen specificity of regulatory T cells capable of preventing transplant rejection, we have developed two different strategies to achieve tolerance to fully mismatched skin grafts in euthymic mice. A combination of nondepleting Abs targeting CD4, CD8, and CD154 (CD40 ligand) induces dominant transplantation tolerance to fully mismatched skin allografts. Such tolerance is antigen-specific, mediated by regulatory T cells, and can be extended through linked suppression to na… CONTINUE READING
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Graft Survival B G rup D ay 0 D ay 28 G 1 G aft + m A bs B M + m A bs G 2 G aft + m A bs m A bs G 3 G aft + m A bs B M G 4 m A bs graft + B M + m A bs G 5 m A bs m A bs

  • T. Barthlott, G. Kassiotis, B. Stockinger
  • J. Exp. Med
  • 2003
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