Donor-specific blood transfusion-induced tolerance in adult rats with a dominant TCR-Vbeta rearrangement in heart allografts.

@article{Douillard1996DonorspecificBT,
  title={Donor-specific blood transfusion-induced tolerance in adult rats with a dominant TCR-Vbeta rearrangement in heart allografts.},
  author={Patrice Douillard and Christophe Pannetier and R{\'e}gis Josien and S{\'e}verine M{\'e}noret and P. Kourilsky and Jean Paul Soulillou and Maria Cristina Cuturi},
  journal={Journal of immunology},
  year={1996},
  volume={157 3},
  pages={1250-60}
}
Following allotransplantation, determinants encoded within the donor MHC are recognized by recipient T lymphocytes through their Ag receptor. In this study, we investigated the TCR Vbeta chain diversity of T cells infiltrating rejected and tolerated heart allografts in a model of donor-specific blood transfusion-induced tolerance in MHC-mismatched congeneic rats. The PCR-based method that we used allows the diversity of Vbeta chains at the complementarity-determining region 3 level to be… CONTINUE READING
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