Donor-specific HLA-DQ antibodies may contribute to poor graft outcome after renal transplantation.

@article{Devos2012DonorspecificHA,
  title={Donor-specific HLA-DQ antibodies may contribute to poor graft outcome after renal transplantation.},
  author={Jennifer M Devos and A Osama Gaber and Richard J Knight and Geoffrey A. Land and Wadi N. Suki and Lillian W. Gaber and Samir J. Patel},
  journal={Kidney international},
  year={2012},
  volume={82 5},
  pages={598-604}
}
Increasing evidence suggests a detrimental effect of donor-specific antibodies directed against the human leukocyte antigen (HLA)-A, -B, and -DR loci on renal allograft outcomes. Limited data exist on the impact of de novo HLA-DQ antibodies. Over a 3-year period, we prospectively monitored 347 renal transplant recipients without pre-transplant donor-specific antibodies for their development de novo. After 26 months of follow-up, 62 patients developed donor-specific antibodies, of which 48 had a… CONTINUE READING

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