Donor-specific B-cell tolerance after ABO-incompatible infant heart transplantation

@article{Fan2004DonorspecificBT,
  title={Donor-specific B-cell tolerance after ABO-incompatible infant heart transplantation},
  author={Xiaohu Fan and A. Ang and S. Pollock-BarZiv and A. Dipchand and P. Ruiz and G. Wilson and J. Platt and L. West},
  journal={Nature Medicine},
  year={2004},
  volume={10},
  pages={1227-1233}
}
Although over 50 years have passed since its first laboratory description, intentional induction of immune tolerance to foreign antigens has remained an elusive clinical goal. We previously reported that the requirement for ABO compatibility in heart transplantation is not applicable to infants. Here, we show that ABO-incompatible heart transplantation during infancy results in development of B-cell tolerance to donor blood group A and B antigens. This mimics animal models of neonatal tolerance… Expand
Failure of Neonatal B-Cell Tolerance Induction by ABO-Incompatible Kidney Grafts in Piglets
Background ABO-incompatible (ABOi) infant heart transplantation results in B-cell tolerance to graft A/B antigens, confirming human susceptibility to acquired immunologic or “neonatal” tolerance asExpand
Tolerance to incompatible ABO blood group antigens is not observed following homograft implantation.
TLDR
Tolerance to incompatible A and B blood group antigens does not occur following placement of ABO-incompatible homografts in childhood, and patients who require transplantation may be able to accept certain A BO-in compatible organs. Expand
ABO‐Compatible Retransplantation After ABO‐Incompatible Infant Heart Transplantation: Absence of Donor Specific Isohemagglutinins
  • S. Kohler, R. Engmann, +4 authors R. Kozlik-Feldmann
  • Medicine
  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2014
TLDR
A case of an infant who underwent ABOi heart transplantation, with no evidence of DSI even 4 years after ABO‐compatible retransplantation is reported, suggesting the possibility of induced permanent B cell tolerance. Expand
Development of B-cell memory in early childhood and the impact on antigen-specific tolerance after heart transplantation.
TLDR
Memory B cells may be quantified to assess eligibility for ABO-incompatible transplant and represent a potential therapeutic target to extend the benefits of the immature immune system to older age groups. Expand
ABO-incompatible heart transplantation
TLDR
Insight is provided into the clinical evolution of ABOi HTx and associated immunologic discoveries and current experiences and boundaries are discussed together with recent and potential future developments for utilization in other patient and age groups. Expand
ABO-incompatible solid-organ transplantation.
TLDR
The stage is set to eliminate ABO as a barrier to solid-organ transplantation. Expand
B cell tolerance and xenotransplantation
TLDR
This review summarizes recent advances in the understanding of B cell tolerance in rodent models and patients and describes strategies for tolerance induction developed in the animal models that may be applied clinically as an understanding of their mechanisms emerges. Expand
B cells and transplantation tolerance
TLDR
This Review comprises a discussion of the mechanisms involved in the induction of B-cell tolerance and a survey of current and emerging therapies that target the effects of B cells in transplant recipients. Expand
Antibodies and ABO‐incompatibility in pediatric transplantation
  • L. West
  • Medicine
  • Pediatric transplantation
  • 2011
TLDR
The unique immunologic nature of infants that the experience reveals has resulted in organ allocation practices evolving in Canada and the UK that facilitate access of children to ABOincompatible donors; thus, patients are listed for transplantation using the first available donor of suitable size, regardless of blood type. Expand
Cryptic B Cell Response to Renal Transplantation
TLDR
The increase in frequency of donor‐specific antibody‐secreting cells after renal transplantation indicates that B cells respond specifically to the transplant donor more often than previously thought. Expand
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