Donor simvastatin treatment abolishes rat cardiac allograft ischemia/reperfusion injury and chronic rejection through microvascular protection.

@article{Tuuminen2011DonorST,
  title={Donor simvastatin treatment abolishes rat cardiac allograft ischemia/reperfusion injury and chronic rejection through microvascular protection.},
  author={Raimo Tuuminen and Simo O Syrj{\"a}l{\"a} and Rainer Krebs and Mikko A. I. Ker{\"a}nen and Katri Koli and Usama Abo-Ramadan and Pertti J. Neuvonen and Jussi M. Tikkanen and Antti I. Nyk{\"a}nen and Karl B. Lemstr{\"o}m},
  journal={Circulation},
  year={2011},
  volume={124 10},
  pages={
          1138-50
        }
}
BACKGROUND Ischemia/reperfusion injury may have deleterious short- and long-term consequences for cardiac allografts. The underlying mechanisms involve microvascular dysfunction that may culminate in primary graft failure or untreatable chronic rejection. METHODS AND RESULTS Here, we report that rat cardiac allograft ischemia/reperfusion injury resulted in profound microvascular dysfunction that was prevented by donor treatment with peroral single-dose simvastatin, a 3-hydroxy-3… CONTINUE READING
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