Donor immune reconstitution after liver-small bowel transplantation for multiple intestinal atresia with immunodeficiency.

@article{Gilroy2004DonorIR,
  title={Donor immune reconstitution after liver-small bowel transplantation for multiple intestinal atresia with immunodeficiency.},
  author={Richard K Gilroy and Peter F. Coccia and James E Talmadge and Lori I. Hatcher and Samuel J. Pirruccello and Byers W. Shaw and Ronald J. Rubocki and Debra Lynn Sudan and Alan N. Langnas and Simon Horslen},
  journal={Blood},
  year={2004},
  volume={103 3},
  pages={1171-4}
}
The syndrome of multiple intestinal atresia with immunodeficiency is a rare, invariably fatal congenital disorder. At 16 months of age, a child with this syndrome underwent liver-small bowel transplantation from a 1-of-6 HLA-matched donor. He acquired full enteral tolerance and normal liver function and has never shown evidence of allograft rejection. After mild graft-versus-host disease developed, studies revealed that more than 99% of his CD3(+) lymphocytes and 50% of his CD19(+) lymphocytes… CONTINUE READING
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