Donor-derived TNF-alpha regulates pulmonary chemokine expression and the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation.

@article{Hildebrandt2004DonorderivedTR,
  title={Donor-derived TNF-alpha regulates pulmonary chemokine expression and the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation.},
  author={Gerhard C. Hildebrandt and Krystyna M. Olkiewicz and Leigh A. Corrion and Yayi Chang and Shawn G. Clouthier and Chen Liu and Kenneth R. Cooke},
  journal={Blood},
  year={2004},
  volume={104 2},
  pages={586-93}
}
Idiopathic pneumonia syndrome (IPS) is a significant cause of mortality after allogeneic bone marrow transplantation (allo-BMT), and tumor necrosis factor-alpha (TNF-alpha) is a significant effector molecule in this process. However, the relative contribution of donor-versus host-derived TNF-alpha to the development of IPS has not been elucidated. Using a lethally irradiated parent --> F1 mouse IPS model, we showed that 5 weeks after transplantation allo-BMT recipients developed significant… CONTINUE READING
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