Donor-derived, metastatic urothelial cancer after kidney transplantation associated with a potentially oncogenic BK polyomavirus.

@article{Mller2018DonorderivedMU,
  title={Donor-derived, metastatic urothelial cancer after kidney transplantation associated with a potentially oncogenic BK polyomavirus.},
  author={David C M{\"u}ller and Maarit R{\"a}m{\"o} and Klaudia Naegele and Sebastian Ribi and C Wetterauer and Valeria Perrina and Luca Quagliata and Tatjana Vlajnic and Christian Ruiz and Beate Balitzki and Rainer Grobholz and Rainer Gosert and Elvis T Ajuh and Hans Hellmuth Hirsch and Lukas Bubendorf and Cyrill A. Rentsch},
  journal={The Journal of pathology},
  year={2018},
  volume={244 3},
  pages={265-270}
}
BK polyomavirus has been linked to urothelial carcinoma in immunosuppressed patients. Here, we performed comprehensive genomic analysis of a BK polyomavirus-associated, metachronous, multifocal and metastatic micropapillary urothelial cancer in a kidney transplant recipient. Dissecting cancer heterogeneity by sorting technologies prior to array-comparative genomic hybridization followed by short tandem repeat analysis revealed that the metastatic urothelial cancer was of donor origin (4-year… CONTINUE READING
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