Donor dendritic cell-derived exosomes promote allograft-targeting immune response.

@article{Liu2016DonorDC,
  title={Donor dendritic cell-derived exosomes promote allograft-targeting immune response.},
  author={Quan Liu and Darling M. Rojas-Canales and Sherrie J. Divito and William J. Shufesky and Donna B Stolz and Geza Erdos and Mara L G Sullivan and Gregory A. Gibson and Simon C Watkins and Adriana T. Larregina and Adrian E Morelli},
  journal={The Journal of clinical investigation},
  year={2016},
  volume={126 8},
  pages={
          2805-20
        }
}
The immune response against transplanted allografts is one of the most potent reactions mounted by the immune system. The acute rejection response has been attributed to donor dendritic cells (DCs), which migrate to recipient lymphoid tissues and directly activate alloreactive T cells against donor MHC molecules. Here, using a murine heart transplant model, we determined that only a small number of donor DCs reach lymphoid tissues and investigated how this limited population of donor DCs… CONTINUE READING

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