Donor and host B cell-derived IL-10 contributes to suppression of graft-versus-host disease.

@article{Weber2014DonorAH,
  title={Donor and host B cell-derived IL-10 contributes to suppression of graft-versus-host disease.},
  author={Michael D Weber and Pamela Stein and Steve Pr{\"u}fer and Berenice M Rudolph and Andreas Kreft and Edgar Schmitt and Tobias Bopp and Axel Roers and Hansjoerg Schild and Simon Fillatreau and Markus P Radsak},
  journal={European journal of immunology},
  year={2014},
  volume={44 6},
  pages={1857-65}
}
Graft-versus-host disease (GvHD) is a frequent life-threatening complication following allogeneic HSC transplantation (HSCT). IL-10 is a regulatory cytokine with important roles during GvHD, yet its relevant sources, and mode of action, remain incompletely defined in this disease. Using IL-10-deficient donor or host mice (BALB/c or C57BL/6, respectively) in a MHC-mismatched model for acute GvHD, we found a strongly aggravated course of the disease with increased mortality when either donor or… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
9 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Similar Papers

Loading similar papers…