Donor T-cell development in host thymus after heterotopic limb transplantation in mice.

@article{Li2007DonorTD,
  title={Donor T-cell development in host thymus after heterotopic limb transplantation in mice.},
  author={Zhanzhuo Li and Fleur Samantha Benghiat and Carole Kubjak and Fr{\'e}d{\'e}ric Schuind and Michel Goldman and Ala{\'i}n Le Moine},
  journal={Transplantation},
  year={2007},
  volume={83 6},
  pages={815-8}
}
We developed a mouse model of heterotopic limb transplantation in which we took advantage of Thy1.1 and Thy1.2 congenic strains to track and characterize donor T cells, to determine the role of recipient's thymus in mixed T-cell chimerism induction as well as transplant immunocompetence. The vascularized Thy1.1 limb graft composed of femur, muscle, and skin (VBT) survived long-term in more than 87.5% of Thy1.2 recipients. Percentages of donor-type Thy1.1 T cells increased from day 30 to 90 in… CONTINUE READING

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