Donor-Recipient Matching for KIR Genotypes Reduces Chronic GVHD and Missing Inhibitory KIR Ligands Protect against Relapse after Myeloablative, HLA Matched Hematopoietic Cell Transplantation

@inproceedings{Faridi2016DonorRecipientMF,
  title={Donor-Recipient Matching for KIR Genotypes Reduces Chronic GVHD and Missing Inhibitory KIR Ligands Protect against Relapse after Myeloablative, HLA Matched Hematopoietic Cell Transplantation},
  author={Rehan Mujeeb Faridi and Taylor J Kemp and Poonam Dharmani-Khan and Victor Anthony Lewis and Gaurav Tripathi and Raja Rajalingam and Andrew Daly and Noureddine Berka and Jan Storek and Faisal Masood Khan},
  booktitle={PloS one},
  year={2016}
}
BACKGROUND Allogeneic hematopoietic cell transplantation (HCT) can be curative for many hematologic diseases. However, complications such as graft-versus-host disease (GVHD) and relapse of primary malignancy remain significant and are the leading causes of morbidity and mortality. Effects of killer Ig-like receptors (KIR)-influenced NK cells on HCT outcomes have been extensively pursued over the last decade. However, the relevance of the reported algorithms on HLA matched myeloablative HCT with… CONTINUE READING