Donor Mesenchymal Stromal Cells (MSCs) Undergo Variable Cardiac Reprogramming in Vivo and Predominantly Co-Express Cardiac and Stromal Determinants after Experimental Acute Myocardial Infarction

@article{Yannarelli2013DonorMS,
  title={Donor Mesenchymal Stromal Cells (MSCs) Undergo Variable Cardiac Reprogramming in Vivo and Predominantly Co-Express Cardiac and Stromal Determinants after Experimental Acute Myocardial Infarction},
  author={Gustavo Yannarelli and James N. Tsoporis and J. S. Desjardins and Xing Wang and Ali Pourdjabbar and Sowmya Viswanathan and Thomas G. Parker and Armand Keating},
  journal={Stem Cell Reviews and Reports},
  year={2013},
  volume={10},
  pages={304-315}
}
We previously showed the emergence of predominantly non-fused murine cells co-expressing cardiac and stromal determinants in co-cultures of murine mesenchymal stromal cells (MSCs) and rat embryonic cardiomyocytes. To determine whether a similar phenotype is detectable in vivo in ischemic myocardium, we infused green fluorescence protein (GFP)-marked MSCs intravenously into wild-type mice in an acute myocardial infarction (AMI) model generated by ischemia/reperfusion (I/R) or fixed coronary… CONTINUE READING
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