Donor Haplotype B of NK KIR Receptor Reduces the Relapse Risk in HLA-Identical Sibling Hematopoietic Stem Cell Transplantation of AML Patients

@inproceedings{Impola2014DonorHB,
  title={Donor Haplotype B of NK KIR Receptor Reduces the Relapse Risk in HLA-Identical Sibling Hematopoietic Stem Cell Transplantation of AML Patients},
  author={Ulla Impola and Hannu Turpeinen and Noora S Alakulppi and T Linjama and Liisa Volin and Riitta Niittyvuopio and Jukka Partanen and Satu Koskela},
  booktitle={Front. Immunol.},
  year={2014}
}
Successful allogeneic hematopoietic stem cell transplantation (HSCT) depends not only on good HLA match but also on T-cell mediated graft-versus-leukemia (GvL) effect. Natural killer (NK) cells are able to kill malignant cells by receiving activation signal from the killer-cell immunoglobulin-like receptors (KIR) recognizing HLA molecules on a cancer cell. It has been recently reported that the risk of relapse in allogeneic hematopoietic stem cell transplantation (HSCT) is reduced in acute… CONTINUE READING
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Decreased infections in recipients of unrelated donor hematopoietic cell transplantation from donors with an activating KIR genotype.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation • 2010
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