Donor DNA in a renal cell carcinoma metastasis from a bone marrow transplant recipient

  title={Donor DNA in a renal cell carcinoma metastasis from a bone marrow transplant recipient},
  author={Anirban Chakraborty and Rossitza Z Lazova and S Davies and Helena B{\"a}ckvall and Fredrik Pont{\'e}n and Don Brash and John M. Pawelek},
  journal={Bone Marrow Transplantation},
Individuals receiving either allogeneic bone marrow transplants, or organ transplants, are at an increased risk of developing de novo malignancies. Radiation and immunosuppression are both risk factors. As unfortunate as this is, it could allow for detection of tumor cell–hematopoietic cell hybrids in human cancer. In animal models, tumor hybrids were documented through the use of heterologous genetic markers for the tumor and host genotypes, in some cases revealing hybridization with… CONTINUE READING


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