Donor CD4+ T and B cells in transplants induce chronic graft-versus-host disease with autoimmune manifestations.

@article{Zhang2006DonorCT,
  title={Donor CD4+ T and B cells in transplants induce chronic graft-versus-host disease with autoimmune manifestations.},
  author={Chunyan Zhang and Ivan Todorov and Zhifang Zhang and Yinping Liu and Fouad Kandeel and Stephen Forman and Samuel Strober and Defu Zeng},
  journal={Blood},
  year={2006},
  volume={107 7},
  pages={2993-3001}
}
Chronic graft-vs-host disease (GVHD) is a major cause of morbidity and mortality of long-term survivors of allogeneic hemato-poietic cell transplantation (HCT). Chronic GVHD can have features of an autoimmune collagen vascular disease with clinical manifestations similar to autoimmune scleroderma and systemic lupus erythematosus (SLE). However, the pathogenesis of chronic GVHD is poorly understood. It is unclear how autoreactive T and B cells are generated in chronic GVHD recipients. We have… CONTINUE READING

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