Donnan effect on chloride ion distribution as a determinant of body fluid composition that allows action potentials to spread via fast sodium channels

@article{Kurbel2011DonnanEO,
  title={Donnan effect on chloride ion distribution as a determinant of body fluid composition that allows action potentials to spread via fast sodium channels},
  author={Sven Kurbel},
  journal={Theoretical Biology \& Medical Modelling},
  year={2011},
  volume={8},
  pages={16 - 16}
}
  • S. Kurbel
  • Published 30 May 2011
  • Biology
  • Theoretical Biology & Medical Modelling
Proteins in any solution with a pH value that differs from their isoelectric point exert both an electric Donnan effect (DE) and colloid osmotic pressure. While the former alters the distribution of ions, the latter forces water diffusion. In cells with highly Cl--permeable membranes, the resting potential is more dependent on the cytoplasmic pH value, which alters the Donnan effect of cell proteins, than on the current action of Na/K pumps. Any weak (positive or negative) electric disturbances… 
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