Donepezil treatment and changes in hippocampal structure in very mild Alzheimer disease.

OBJECTIVE To compare longitudinal changes in the hippocampal structure in subjects with very mild dementia of the Alzheimer type (DAT) treated with donepezil hydrochloride, untreated subjects with very mild DAT, and controls without dementia. DESIGN MPRAGE sequences were collected approximately 2 years apart on two 1.5-T magnetic resonance imaging systems… CONTINUE READING