Donepezil-induced REM sleep augmentation enhances memory performance in elderly, healthy persons

@article{Schredl2001DonepezilinducedRS,
  title={Donepezil-induced REM sleep augmentation enhances memory performance in elderly, healthy persons},
  author={Michael Schredl and Bettina Weber and M. -L Leins and Isabella Heuser},
  journal={Experimental Gerontology},
  year={2001},
  volume={36},
  pages={353-361}
}
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97 Citations
Background Citations
22
Methods Citations
2
Results Citations
4

97 Citations

Citation Type

Citation Type

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    Perspectives on psychological science : a journal of the Association for Psychological Science
  • 2015
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The literature is interpreted as suggesting that maintaining good sleep quality, at least in young adulthood and middle age, promotes better cognitive functioning and serves to protect against age-related cognitive declines.
[Nightmares in patients with Alzheimer's disease caused by donepezil. Therapeutic effect depends on the time of intake].
TLDR
It is suggested that the activation of the visual association cortex during REM sleep is enhanced by donepezil, a mechanism most likely facilitating the development of nightmares in patients with DAT.
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Non-sleep related factors, low cortisol levels and low acetylcholine levels in the first part of the night have been shown to be important in early sleep-dependent declarative memory; demonstrating the importance of considering circadian effects.
Does age worsen sleep‐dependent memory consolidation?
TLDR
In older adults, sleep did not enhance memory consolidation significantly compared to wakefulness, and age‐related changes in sleep parameters may have a negative impact on memory consolidation in older adults.
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