Donepezil in patients with severe Alzheimer's disease: double-blind, parallel-group, placebo-controlled study.

@article{Winblad2006DonepezilIP,
  title={Donepezil in patients with severe Alzheimer's disease: double-blind, parallel-group, placebo-controlled study.},
  author={Bengt Winblad and Lena Kilander and Sture Eriksson and Lennart Minthon and Stellan B{\aa}tsman and Anna-Lena Wetterholm and Catarina Jansson-Blixt and Anders Haglund},
  journal={Lancet},
  year={2006},
  volume={367 9516},
  pages={
          1057-1065
        }
}
BACKGROUND The cholinesterase inhibitor donepezil is used to treat mild-to-moderate Alzheimer's disease. Its efficacy in severe dementia has not been assessed and is controversial. Our aim was to ascertain the effectiveness of donepezil in patients with severe Alzheimer's disease, by focusing primarily on cognition and activities of daily living. METHODS We did a 6-month, double-blind, parallel-group, placebo-controlled study in 248 patients with severe Alzheimer's disease (mini mental state… CONTINUE READING
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Memantine in moderate to severe Alzheimer's disease.

Current neurology and neuroscience reports • 2003

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