Donepezil in Alzheimer’s disease: From conventional trials to pharmacogenetics

  title={Donepezil in Alzheimer’s disease: From conventional trials to pharmacogenetics},
  author={Ram{\'o}n Cacabelos},
  journal={Neuropsychiatric Disease and Treatment},
  pages={303 - 333}
Donepezil is the leading compound for the treatment of Alzheimer's disease (AD) in more than 50 countries. As compared with other conventional acetylcholinesterase inhibitors (AChEIs), donepezil is a highly selective and reversible piperidine derivative with AChEI activity that exhibits the best pharmacological profile in terms of cognitive improvement, responders rate (40%-58%), dropout cases (5%-13%), and side-effects (6%-13%) in AD. Although donepezil represents a non cost-effective… CONTINUE READING


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