Donepezil improves obstructive sleep apnea in Alzheimer disease: a double-blind, placebo-controlled study.

@article{Moraes2008DonepezilIO,
  title={Donepezil improves obstructive sleep apnea in Alzheimer disease: a double-blind, placebo-controlled study.},
  author={Walter Andr{\'e} dos Santos Moraes and Dalva Lucia Rollemberg Poyares and Lucia Sukys-Claudino and Christian Guilleminault and Sergio Brasil Tufik},
  journal={Chest},
  year={2008},
  volume={133 3},
  pages={677-83}
}
BACKGROUND There is an association between Alzheimer disease and sleep-disordered breathing. Donepezil is the drug most frequently used to treat cognitive symptoms in Alzheimer disease. This study evaluates the effects of donepezil on obstructive sleep apnea in patients with Alzheimer disease. METHODS Randomized, double-blind, placebo-controlled design. Twenty-three patients with mild-to-moderate Alzheimer disease and apnea-hypopnea index (AHI) > 5/h were allocated to two groups: donepezil… CONTINUE READING
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