Donepezil improves cognitive function in mice by increasing the production of insulin-like growth factor-I in the hippocampus.

@article{Narimatsu2009DonepezilIC,
  title={Donepezil improves cognitive function in mice by increasing the production of insulin-like growth factor-I in the hippocampus.},
  author={Noriko Narimatsu and Naoaki Harada and Hiroki Kurihara and Naomi Nakagata and Kazuya Sobue and Kenji Okajima},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2009},
  volume={330 1},
  pages={2-12}
}
Insulin-like growth factor-I (IGF-I) exerts beneficial effects on cognitive function. The selective acetylcholinesterase inhibitor donepezil increases serum IGF-I levels in elderly subjects. Because stimulation of sensory neurons induces IGF-I production by releasing calcitonin gene-related peptide (CGRP) in the mouse brain, we hypothesized that donepezil increases IGF-I production by sensory neuron stimulation to improve the cognitive function in mice. Donepezil, but not tacrine, increased the… CONTINUE READING

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