Donepezil enhances Purkinje cell survival and alleviates motor dysfunction by inhibiting cholesterol synthesis in a murine model of Niemann Pick disease type C.

@article{Seo2014DonepezilEP,
  title={Donepezil enhances Purkinje cell survival and alleviates motor dysfunction by inhibiting cholesterol synthesis in a murine model of Niemann Pick disease type C.},
  author={Yoojin Seo and Yooyoung Shin and Hyung-Sik Kim and InSung Kang and In-Sun Hong and Soon Won Choi and Kyung-Rok Yu and K Kang},
  journal={Journal of neuropathology and experimental neurology},
  year={2014},
  volume={73 3},
  pages={234-43}
}
Neurodegenerative processes are often accompanied by disruption of cholinergic systems; therefore, acetylcholinesterase (AChE) inhibitors (AChEIs) may have therapeutic potential in some neurological conditions. We evaluated the effects of administration of donepezil, a widely used AChEI, in the cerebellum in a murine model of Niemann-Pick disease type C (NPC). The NPC mice developed Purkinje cell loss at the age of 8 weeks; 4-week-old NPC mice given donepezil led to improvement of Purkinje cell… CONTINUE READING
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