Donepezil Plus Solifenacin (CPC-201) Treatment for Alzheimer’s Disease

  title={Donepezil Plus Solifenacin (CPC-201) Treatment for Alzheimer’s Disease},
  author={Thomas N. Chase and Martin R. Farlow and Kathleen Clarence-Smith},
Available cholinergic drugs for treating Alzheimer’s disease (AD) provide modest symptomatic benefit. We hypothesized that co-administration of a peripheral anticholinergic to reduce dose-limiting adverse effects (AEs) would enable the safe/tolerable use of higher cholinesterase inhibitor doses and thus improve their antidementia efficacy. A modified single-blind, ascending-dose, phase IIa study of donepezil plus solifenacin (CPC-201) lasting 26 weeks was conducted in 41 patients with probable… CONTINUE READING
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High dose cholinesterase inhibitor treatment of Alzheimer’s disease

  • TN Chase, K. Clarence-Smith
  • AAIC Abstract #2729l,
  • 2015
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