Donepezil: a review.

  title={Donepezil: a review.},
  author={Ben Seltzer},
  journal={Expert opinion on drug metabolism & toxicology},
  volume={1 3},
  • Ben Seltzer
  • Published 2005 in Expert opinion on drug metabolism & toxicology
Donepezil is a selective acetylcholinesterase inhibitor that is widely prescribed for Alzheimer's disease (AD). It has been shown to be of benefit in mild, moderate and severe stages of AD, vascular dementia and dementia associated with Parkinson's disease. Donepezil is absorbed slowly, but completely, from the gut, reaching peak plasma levels in 3-4 h and, with daily dosing, steady-state concentration in 15-21 days. Within a relatively narrow range, there is a linear relationship between dose… CONTINUE READING


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