Don't mess with the matrix

  title={Don't mess with the matrix},
  author={Thiennu H. Vu},
  journal={Nature Genetics},
Extracellular matrix (ECM) remodeling is critical to morphogenesis and homeostasis. The identification of inactivating mutations in a gene encoding one of its modifying enzymes, matrix metalloproteinase 2 (MMP-2), in people with a hereditary disorder in which the bones disintegrate, represents the first genetic evidence that the proteolysis of the ECM… CONTINUE READING