Domperidone antagonizes the relaxant effect atropine on the lower esophageal sphincter.

Abstract

A zone of increased intraluminal pressure exists at the gastroesophageal junction in man and is believed to act as a physiologic sphincter. Increasing this lower esophageal sphincter (LES) tone is an accepted and useful method in preventing gastroesophageal reflux. The effects of LES tone were studied in 10 healthy volunteers receiving sequential… (More)

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Cite this paper

@article{Brockutne1980DomperidoneAT, title={Domperidone antagonizes the relaxant effect atropine on the lower esophageal sphincter.}, author={J G Brock-utne}, journal={Anesthesia and analgesia}, year={1980}, volume={59 12}, pages={921-4} }