Domperidone and Risk of Ventricular Arrhythmia and Cardiac Death: A Systematic Review and Meta-analysis

@article{Leelakanok2015DomperidoneAR,
  title={Domperidone and Risk of Ventricular Arrhythmia and Cardiac Death: A Systematic Review and Meta-analysis},
  author={N. Leelakanok and A. Holcombe and M. Schweizer},
  journal={Clinical Drug Investigation},
  year={2015},
  volume={36},
  pages={97-107}
}
  • N. Leelakanok, A. Holcombe, M. Schweizer
  • Published 2015
  • Medicine
  • Clinical Drug Investigation
  • Background and ObjectiveDomperidone is a drug used globally for relieving nausea and vomiting and stimulating breast milk production. Several case reports and studies linked domperidone usage with major cardiovascular adverse events (cardiac arrhythmia and sudden cardiac death). However, multiple randomized controlled efficacy studies failed to detect such adverse events. Our objectives were to systematically review and meta-analyze the association between current domperidone exposure and… CONTINUE READING
    41 Citations
    A meta-analysis on the cardiac safety profile of domperidone compared to metoclopramide
    • 11
    Risk of domperidone induced severe ventricular arrhythmia
    • PDF
    Effect of Chronic Domperidone Use on QT Interval
    • 7
    Awareness of, and Compliance with, Domperidone Revised Labeling After a Risk-Minimization Activity in Europe
    • 1
    • Highly Influenced
    • PDF
    Gastroparesis: pharmacotherapy and cardiac risk
    • 5
    Chinese herbal medicine for functional dyspepsia: systematic review of systematic reviews
    • 14
    • PDF

    References

    SHOWING 1-10 OF 51 REFERENCES
    [Cardiac adverse effects of domperidone in adult patients: a systematic review].
    • 4
    • PDF
    Domperidone and long QT syndrome.
    • 61
    Domperidone and Ventricular Arrhythmia or Sudden Cardiac Death
    • 137
    • Highly Influential
    Cardiovascular Safety Profile and Clinical Experience With High-Dose Domperidone Therapy for Nausea and Vomiting
    • 29
    • PDF
    Non-cardiac QTc-prolonging drugs and the risk of sudden cardiac death.
    • 210
    • PDF
    Sudden death in patients receiving drugs tending to prolong the QT interval.
    • 52
    • Highly Influential
    Cardiac safety concerns for domperidone, an antiemetic and prokinetic, and galactogogue medicine
    • 52
    • Highly Influential
    • PDF
    Effect of Domperidone on Insufficient Lactation in Puerperal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
    • 40
    • PDF