Domperidone and Risk of Ventricular Arrhythmia and Cardiac Death: A Systematic Review and Meta-analysis

  title={Domperidone and Risk of Ventricular Arrhythmia and Cardiac Death: A Systematic Review and Meta-analysis},
  author={N. Leelakanok and A. Holcombe and M. Schweizer},
  journal={Clinical Drug Investigation},
  • N. Leelakanok, A. Holcombe, M. Schweizer
  • Published 2015
  • Medicine
  • Clinical Drug Investigation
  • Background and ObjectiveDomperidone is a drug used globally for relieving nausea and vomiting and stimulating breast milk production. Several case reports and studies linked domperidone usage with major cardiovascular adverse events (cardiac arrhythmia and sudden cardiac death). However, multiple randomized controlled efficacy studies failed to detect such adverse events. Our objectives were to systematically review and meta-analyze the association between current domperidone exposure and… CONTINUE READING
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