Domperidone Treatment for Gastroparesis: Demographic and Pharmacogenetic Characterization of Clinical Efficacy and Side-Effects

  title={Domperidone Treatment for Gastroparesis: Demographic and Pharmacogenetic Characterization of Clinical Efficacy and Side-Effects},
  author={H. Parkman and M. Jacobs and A. Mishra and Jessica A. Hurdle and P. Sachdeva and J. Gaughan and Evgeny Krynetskiy},
  journal={Digestive Diseases and Sciences},
  • H. Parkman, M. Jacobs, +4 authors Evgeny Krynetskiy
  • Published 2010
  • Biology, Medicine
  • Digestive Diseases and Sciences
  • BackgroundDomperidone is a useful alternative to metoclopramide for treatment of gastroparesis due to better tolerability. Effectiveness and side-effects from domperidone may be influenced by patient-related factors including polymorphisms in genes encoding drug-metabolizing enzymes, drug transporters, and domperidone targets.AimsThe aim of this study was to determine if demographic and pharmacogenetic parameters of patients receiving domperidone are associated with response to treatment or… CONTINUE READING
    46 Citations
    Association between polymorphism of dopamine D2 receptor genes and therapeutic effect of domperidone in functional dyspepsia.
    • Z. Xiang, Han Ma, Yun Mou, C. F. Xu
    • Medicine
    • The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
    • 2015
    • 3
    • PDF
    The role of pharmacogenetics in nonmalignant gastrointestinal diseases
    • M. Camilleri
    • Medicine
    • Nature Reviews Gastroenterology &Hepatology
    • 2012
    • 8
    Identification of domperidone metabolites in plasma and urine of gastroparesis patients with LC–ESI-MS/MS
    • 5
    Clinical implications of neuropharmacogenetics.
    • 1
    • PDF
    The investigational drug camicinal for the treatment of gastroparesis
    • 12


    Comparative evaluation of the efficacy and tolerability of itopride hydrochloride and domperidone in patients with non-ulcer dyspepsia.
    • 32
    • PDF
    Role of a KCNH2 polymorphism (R1047 L) in dofetilide-induced Torsades de Pointes.
    • 57
    Pharmacogenetics/genomics and personalized medicine.
    • 190
    • PDF
    The missing linkage: what pharmacogenetic associations are left to find in CYP3A?
    • M. Perera
    • Biology, Medicine
    • Expert opinion on drug metabolism & toxicology
    • 2010
    • 43
    Substrate-Dependent Effects of Human ABCB1 Coding Polymorphisms
    • 49
    A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function.
    • 284
    Identification of the cytochrome P450 enzymes involved in the metabolism of domperidone
    • 21