Domperidone; secretion in breast milk and effect on puerperal prolactin levels

@article{Hofmeyr1985DomperidoneSI,
  title={Domperidone; secretion in breast milk and effect on puerperal prolactin levels},
  author={G Justus Hofmeyr and Basil van Iddekinge and J A Blott},
  journal={BJOG: An International Journal of Obstetrics \& Gynaecology},
  year={1985},
  volume={92}
}
Summary. The possible effect on the infant of dopamine antagonists used to promote lactation is cause for concern. Domperidone (Motilium) may be safer than other drugs in this group as it does not cross the blood‐brain barrier. The mean serum level of prolactin 2 h after treatment with 20 mg of domperidone in the puerperium was 255 ng/ml compared with 150 ng/ml after a placebo. The mean domperidone level in all breast milk samples during treatment with 10mg, three times daily, was 2·6 ng/ml… Expand
Effect of parity on pituitary prolactin response to metoclopramide and domperidone: implications for the enhancement of lactation.
TLDR
The gastrointestinal motility agents metoclopramide and domperidone are known to increase pituitary prolactin (PRL) secretion and breast milk production and this study compared the effect of these agents on these parameters. Expand
Dose-effect study of domperidone as a galactagogue in preterm mothers with insufficient milk supply, and its transfer into milk.
TLDR
In one-third of mothers, domperidone did not increase milk production, and there was a trend for a dose-response relationship, and infant exposure via breastfeeding was not considered to be significant. Expand
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TLDR
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TLDR
A dose of domperidone of 20 mg, 3 times daily instead of 10 mg,3 times daily was associated with a clinical, but not statistically significant, increase in milk production, which was not significant within- or between-group difference. Expand
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TLDR
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TLDR
If domperidone causes significant changes to the nutrient content of breast milk, an alteration in feeding practices for preterm infants may need to be made in order to optimize growth, nutrition and neurodevelopment outcomes. Expand
Metoclopramide or domperidone for increasing maternal breast milk output: a randomised controlled trial
TLDR
Oral domperidone and metoclopramide increased the volume of milk produced by mothers who are expressing to feed their babies in NICU, and there were small differences in milk output between the two medications. Expand
Use of Domperidone as a Galactagogue Drug
  • C. Paul, M. Zénut, +4 authors D. Balayssac
  • Medicine
  • Journal of human lactation : official journal of International Lactation Consultant Association
  • 2015
TLDR
The benefit-risk ratio of domperidone as a galactagogue was assessed following a literature search of the PubMed database up to July 2013 and an improvement of breastfeeding practices seems to be more effective and safer than the use of an off-label domperidine treatment. Expand
Effect of Domperidone on Insufficient Lactation in Puerperal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
TLDR
Evidence from a few small RCTs of moderate to high quality suggests that domperidone produces a greater increase in breast milk supply than placebo. Expand
Secretion of the gastrokinetic agent cisapride in human milk
TLDR
Ten puerperal women were treated with the gastrokinetic agent Cisapride 20 mg 8-h by oral tablets to treat breast milk levels and serum levels, and the breastfeeding infant of a woman on the above treatment would ingest an amount of CisAPride 600–800 times lower than the usual therapeutic dose. Expand
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