Dominant transformation by mutated human ras genes in vitro requires more than 100 times higher expression than is observed in cancers.

@article{Hua1997DominantTB,
  title={Dominant transformation by mutated human ras genes in vitro requires more than 100 times higher expression than is observed in cancers.},
  author={V Y Hua and W K Wang and Peter H. Duesberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 18},
  pages={9614-9}
}
The gene-mutation-cancer hypothesis holds that mutated cellular protooncogenes, such as point-mutated proto-ras, "play a dominant part in cancer," because they are sufficient to transform transfected mouse cell lines in vitro [Alberts, B., Bray, D., Lewis, J., Raff, M., Roberts, K. & Watson, J. D. (1994) Molecular Biology of the Cell (Garland, New York)]. However, in cells transformed in vitro mutated human ras genes are expressed more than 100-fold than in the cancers from which they are… CONTINUE READING
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