Dominant roles of the polybasic proline motif and copper in the PrP23-89-mediated stress protection response.

Abstract

Beta-cleavage of the neurodegenerative disease-associated prion protein (PrP) protects cells from death induced by oxidative insults. The beta-cleavage event produces two fragments, designated N2 and C2. We investigated the role of the N2 fragment (residues 23-89) in cellular stress response, determining mechanisms involved and regions important for this… (More)
DOI: 10.1242/jcs.043604

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Cite this paper

@article{Haigh2009DominantRO, title={Dominant roles of the polybasic proline motif and copper in the PrP23-89-mediated stress protection response.}, author={Cathryn L Haigh and Simon C Drew and Martin P Boland and Colin L. Masters and Kevin Jeffrey Barnham and Victoria A. Lawson and Steven J Collins}, journal={Journal of cell science}, year={2009}, volume={122 Pt 10}, pages={1518-28} }