Dominant role of mitochondria in calcium homeostasis of single rat pituitary corticotropes.

@article{Lee2005DominantRO,
  title={Dominant role of mitochondria in calcium homeostasis of single rat pituitary corticotropes.},
  author={Andy H. Lee and Amy Tse},
  journal={Endocrinology},
  year={2005},
  volume={146 11},
  pages={4985-93}
}
The rise in cytosolic free Ca2+ concentration ([Ca2+]i) is the major trigger for secretion of ACTH from pituitary corticotropes. To better understand the shaping of the Ca2+ signal in corticotropes, we investigated the mechanisms regulating the depolarization-triggered Ca2+ signal using patch-clamp techniques and indo-1 fluorometry. The rate of cytosolic… CONTINUE READING