Dominant role of copper in the kinetic stability of Cu/Zn superoxide dismutase.

@article{Lynch2006DominantRO,
  title={Dominant role of copper in the kinetic stability of Cu/Zn superoxide dismutase.},
  author={Sandra M Lynch and Wilfredo Col{\'o}n},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={340 2},
  pages={457-61}
}
Mutations in Cu/Zn superoxide dismutase (SOD) are involved in some cases of familial amyotrophic lateral sclerosis, and it appears that misfolding and aggregation, perhaps mediated by abnormal binding or loss of copper (Cu) and/or zinc (Zn), may play a pathological role. It is known that the absence of both metals kinetically destabilizes wild type and mutant SOD leading to a 60-fold increase in their rate of unfolding. Here, the individual contributions of Cu and Zn to the kinetic stability of… CONTINUE READING

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