Dominant role of L- and P-selectin in mediating CXC chemokine-induced neutrophil migration in vivo.

@article{Miotla2001DominantRO,
  title={Dominant role of L- and P-selectin in mediating CXC chemokine-induced neutrophil migration in vivo.},
  author={Jadwiga M. Miotla and Victoria Ridger and Paul G. Hellewell},
  journal={British journal of pharmacology},
  year={2001},
  volume={133 4},
  pages={550-6}
}
The role of selectins in neutrophil emigration in response to the CXC chemokines KC and MIP-2 was investigated in wild type and P-selectin deficient mice. Intrapleural injection of KC or MIP-2 induced a rapid and specific neutrophil accumulation. Emigration 2 h after KC or MIP-2 was reduced 83 - 88% by anti-L-selectin mAb and 53 - 63% by anti-P-selectin mAb. Co-administration of anti-L- and P-selectin mAbs abolished neutrophil migration induced by either chemokine. An anti-E-selectin mAb tested… CONTINUE READING