Dominant-negative suppression of HNF-1 alpha results in mitochondrial dysfunction, INS-1 cell apoptosis, and increased sensitivity to ceramide-, but not to high glucose-induced cell death.

@article{Wobser2002DominantnegativeSO,
  title={Dominant-negative suppression of HNF-1 alpha results in mitochondrial dysfunction, INS-1 cell apoptosis, and increased sensitivity to ceramide-, but not to high glucose-induced cell death.},
  author={Hella Wobser and Heiko D{\"u}ssmann and Donat K{\"o}gel and Haiyan Wang and Claus Reimertz and Claes B Wollheim and Maria M. Byrne and Jochen H. M. Prehn},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 8},
  pages={6413-21}
}
Maturity onset diabetes of the young (MODY) 3 is a monogenic form of diabetes caused by mutations in the transcription factor hepatocyte nuclear factor (HNF)-1 alpha. We investigated the involvement of apoptotic events in INS-1 insulinoma cells overexpressing wild-type HNF-1 alpha (WT-HNF-1 alpha) or a dominant-negative mutant (DN-HNF-1 alpha) under control of a doxycycline-dependent transcriptional activator. Forty-eight h after induction of DN-HNF-1 alpha, INS-1 cells activated caspase-3 and… CONTINUE READING

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