Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia

@article{Pabst2001DominantnegativeMO,
  title={Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-$\alpha$ (C/EBP$\alpha$), in acute myeloid leukemia},
  author={Thomas Pabst and Beatrice U. Mueller and Pu Zhang and Hanna S. Radomska and Sailaja Narravula and Susanne Schnittger and Gerhard Behre and Wolfgang Hiddemann and Daniel Geoffrey Tenen},
  journal={Nature Genetics},
  year={2001},
  volume={27},
  pages={263-270}
}
The transcription factor C/EBPα (for CCAAT/enhancer binding protein-α; encoded by the gene CEBPA) is crucial for the differentiation of granulocytes. Conditional expression of C/EBPα triggers neutrophilic differentiation, and no mature granulocytes are observed in Cebpa-mutant mice. Here we identify heterozygous mutations in CEBPA in ten patients with acute myeloid leukemia (AML). We found that five mutations in the amino terminus truncate the full-length protein, but did not affect a 30-kD… Expand

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  • K. Wagner, Pu Zhang, +7 authors D. Tenen
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2006
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