Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia

@article{Pabst2001DominantnegativeMO,
  title={Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia},
  author={T. Pabst and B. Mueller and P. Zhang and H. Radomska and S. Narravula and S. Schnittger and G. Behre and W. Hiddemann and Daniel G. Tenen},
  journal={Nature Genetics},
  year={2001},
  volume={27},
  pages={263-270}
}
  • T. Pabst, B. Mueller, +6 authors Daniel G. Tenen
  • Published 2001
  • Biology
  • Nature Genetics
  • The transcription factor C/EBPα (for CCAAT/enhancer binding protein-α; encoded by the gene CEBPA) is crucial for the differentiation of granulocytes. Conditional expression of C/EBPα triggers neutrophilic differentiation, and no mature granulocytes are observed in Cebpa-mutant mice. Here we identify heterozygous mutations in CEBPA in ten patients with acute myeloid leukemia (AML). We found that five mutations in the amino terminus truncate the full-length protein, but did not affect a 30-kD… CONTINUE READING

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