Dominant-negative mutant thyroid hormone receptors prevent transcription from Xenopus thyroid hormone receptor beta gene promoter in response to thyroid hormone in Xenopus tadpoles in vivo.

@article{Ulisse1996DominantnegativeMT,
  title={Dominant-negative mutant thyroid hormone receptors prevent transcription from Xenopus thyroid hormone receptor beta gene promoter in response to thyroid hormone in Xenopus tadpoles in vivo.},
  author={Salvatore Ulisse and Graeme Esslemont and Bruce S. Baker and Vijay Krishna and Krishna Chatterjee and Jamshed R. Tata},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 3},
  pages={1205-9}
}
We describe a dominant-negative approach in vivo to assess the strong, early upregulation of thyroid hormone receptor beta (TR beta) gene in response to thyroid hormone, characteristic of the onset of natural and thyroid hormone-induced amphibian metamorphosis, 3,3',5-Triiodo-thyronine (T3) treatment of organ cultures of premetamorphic Xenopus tadpole tails coinjected in vivo with the wild-type Xenopus TR beta (wt-xTR beta) and three different thyroid responsive element chloramphenicol… CONTINUE READING