Dominant negative lptE mutation that supports a role for LptE as a plug in the LptD barrel.


Lipopolysaccharide (LPS) is the major outer leaflet constituent of the Gram-negative outer membrane (OM) bilayer. A bipartite protein complex of LptD and LptE assembles LPS into the OM. It has been established that LptE assists folding and assembly of its β-barrel partner LptD, yet reported biochemical evidence suggested additional LptE functions. Here, we… (More)
DOI: 10.1128/JB.02142-12


8 Figures and Tables