Dominant negative knockout of p53 abolishes ErbB2-dependent apoptosis and permits growth acceleration in human breast cancer cells

@article{Huang2002DominantNK,
  title={Dominant negative knockout of p53 abolishes ErbB2-dependent apoptosis and permits growth acceleration in human breast cancer cells},
  author={Guo Cai Huang and Stephen M. Hobbs and Michael I. Walton and Richard J. Epstein},
  journal={British Journal of Cancer},
  year={2002},
  volume={86},
  pages={1104 - 1109}
}
We previously reported that the ErbB2 oncoprotein prolongs and amplifies growth factor signalling by impairing ligand-dependent downregulation of hetero-oligomerised epidermal growth factor receptors. Here we show that treatment of A431 cells with different epidermal growth factor receptor ligands can cause growth inhibition to an extent paralleling ErbB2 tyrosine phosphorylation. To determine whether such growth inhibition signifies an interaction between the cell cycle machinery and ErbB2… CONTINUE READING

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Proceedings of the National Academy of Sciences of the United States of America • 1997
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